HEALTH: Do males and females age differently? Deteriorate differently as they age? You bet !

Researchers have a blunt phrase for how the sexes age: “Women get sicker, but men die quicker.” By age 80, surviving men are actually in much better physical and cognitive shape than surviving women.

This male-female health-survival paradox comes down to the types of diseases that affect each sex. Men are highly susceptible to acute, fatal conditions, particularly cardiovascular diseases like heart attacks and strokes. Women are more prone to chronic, debilitating, non-fatal conditions. After menopause, women experience a rapid decline in estrogen, leading to lower bone density and making them far more susceptible to osteoporosis and fractures. Women also suffer from higher rates of osteoarthritis, autoimmune diseases, and Alzheimer’s disease.

Men: elite survivors
This creates an “elite survivor” effect among men. Because male mortality is so high in their 60s and 70s, the men who actually make it to 80—and especially those who reach 90 or 100—are a highly filtered subset of the population. They are biologically robust individuals who managed to avoid the fatal heart conditions that killed their peers. Women, protected by the cardiovascular benefits of estrogen earlier in life, survive at much higher rates, but they spend those extra years accumulating physical disabilities.

Muscle mass also plays a significant role in how frailty manifests. Both sexes experience sarcopenia, the age-related loss of muscle mass. However, men generally enter old age with a significantly higher peak muscle mass. This gives them a larger biological buffer before they cross the critical threshold where muscle loss translates into a loss of mobility and independence.

As a result, an 85-year-old woman is statistically much more likely than an 85-year-old man to require assistance with daily activities, use a walker, or live with chronic pain. The paradox of aging is that the biological advantages allowing women to outlive men also leave them enduring a longer period of physical deterioration at the end of life.

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